|RIVASTIGMINE (oral route) – ri-va-STIG meen
|Commonly used brand name(s)
In the U.S
Available Dosage Forms:
Therapeutic Class: Central Nervous System Agent
Pharmacologic, Class: Cholinesterase Inhibitor, Centrally Acting
Uses For This Medicine
|Rivastigmineis used to treat the symptoms of mild to moderate Alzheimer's disease. Rivastigmine will not cure alzheimers disease, and it will not stop the disease from getting worse. However, rivastigmine can improve thinking ability, some patients with Alzheimer's disease.
In Alzheimers disease, many chemical changes take place in the brain. One of the earliest and biggest changes is that there is less of a chemical called acetylcholine (ACh). ACh helps the brain to work properly. Rivastigmine slow the breakdown of ACh, so it can build up and have a greater effect. However, as Alzheimer's disease gets worse, there will be less and less ACh; so rivastigmine may not work as well.
This medicine is available only with your doctor's prescription.
|Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered.
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives or animals. For non-prescription products. Read the label or package ingredients carefully.
Pediatric- Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of rivastigmine in children with use in other age groups.
Geriatric- Studies on rivastigmine have been done only in middle-aged and older patients. Information on the effects of rivastigmine is based on these patients.
||Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus
Breast Feeding- There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding
Other medicines- Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or non prescription (over the-counter [OTC]) medicine)
Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems- The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially
• Asthma (or history of) or
• Blockage in the intestines or stomach, or
• Heart problems, including slow heartbeat or hypotension (low blood pressure), or
• Stomach ulcer (or history of) or
• Urinary tract blockage or difficult urination-Rivastigmine may make these conditions worse
• Epilepsy or history of seizures or
• Diabetes, hormone, or thyroid problems that are poorly controlled-Rivastigmine may cause seizures.
|Proper Use of This Medicine
|Take this medicine only as directed by your doctor .Do not take more or less of it, and do not lake it more or less often than your doctor ordered. Taking too much may increase the chance of side effects, while taking too little may not improve your condition
Rivastigmine is best taken with food.
Rivastigmine seems to work best when it is taken at regularly spaced times, usually two times a day, in the morning and evening.
Dosing The dose of this medicine will be different for diffrerent patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (capsules):
For treatment of Alzheimer’s disease:
• Adults- TO start, 1.5 milligrams (mg) twice a day. Your doctor may increase your dose gradually if you are doing well on this medicine. However, the dose is usually not more than 6 mg twice a day.
Missed dose if you miss a dose of this medicine. Take it as soon as possible. However, if it is almost time for your next does skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
|Precautions While Using This Medicine
|It is very important that your doctor check your progress at regular visits.
Tell your doctor if your symptoms get worst or if you notice any new symptoms.
Before you have any kind of surgery, dental treatment, or emergency treatment, tell the doctor medical doctor or dentist in charge that you am taking this medicine. Taking rivastigmine together with medicines that are sometimes used during surgery or dental or emergency treatments may increase the effects of these medicines.
Rivastigmine may cause some people to become dizzy, clumsy, or unsteady. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.
Rivastigmine causes a large number of patients to have problems with their stomachs and intestines. Tell your doctor about any nausea, vomiting, stomach pain or low of appetite.
Do not stop taking this medicine or decrease your dose without first checking with your doctor. Stopping this medicine suddenly or decreasing the dose by a large amount may cause mental or behavior changes.
If you think you or someone else may have taken an overdose of Rivastigmine, get emergency help at once. Taking an overdose of Rivastigmine may lead to convulsions (seizures) or shock. Some signs of shock are large pupils, irregular breathing, and fast weak pulse. Other signs of an overdose are severe nausea and vomiting, increasing muscle weakness, greatly increased sweating, and greatly increased watering of the mouth.
|Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Cheek with your doctor as soon as possible if any of the following side effects occur.
Diarrhea; indigestion, loss of appetite; loss of strength; nausea and vomiting; weight loss
High blood pressure; fainting
Aggression; convulsions (seizures); trembling and shaking of hands and fingers; trouble in urinating
Symptoms of overdose
Seizures; fast weak pulse; greatly increased sweating; greatly increased watering of mouth; irregular breathing; increasing muscle weakness; large pupils; low blood pressure; nausea; slow heartbeat; vomiting (severe)
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your healthcare professional if any of the following side effects Continue or are bothersome or if you have any questions about them:
Abdominal or stomach pain or cramping; bloated full feeling; confusion; constipation; mental depression; dizziness; fatigue; headache; seeing, hearing, or feeling things that are not there; trouble in sleeping
General feeling of discomfort or illness; increased sweating; runny nose
Other side effects not listed may also occur in some patients. If you notice any other effects, cheek with your healthcare professional.